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Cedars-Sinai Postdoctoral Scientist - Organoid Research - Barrett Lab in Los Angeles, California

Principal Investigator, Robert Barrett, PhD is looking for a Postdoctoral Scientist to join the team!

The Barrett Lab utilizes human intestinal organoids to study various components of inflammatory bowel disease. We are seeking a Postdoc with an interest in gastrointestinal disorders/inflammatory bowel disease (IBD) to join a funded study to elucidate novel mechanisms underpinning human intestinal fibrosis.

This study will adopt a personalized approach whereby iPSC-derived human intestinal organoids from Crohn’s disease patients will be used to determine how various components such as cytokines and cell-cell interactions each play a role in this process. This study is facilitated through our affiliation with the Inflammatory Bowel and Immunobiology Research Institute (IBIRI) which allows for the collection of biospecimens from a well characterized IBD cohort and our organ-on-chip technology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009013/

The Barrett Lab ( https://www.cedars-sinai.org/research/labs/barrett.html ) is located in the Board of Governors Regenerative Medicine Institute ( https://www.cedars-sinai.org/research/departments-institutes/regenerative-medicine.html ) and is affiliated with the Inflammatory Bowel and Immunobiology Research Institute ( https://www.cedars-sinai.org/research/departments-institutes/ibiri/about.html ).

Are you a passionate and dedicated research professional?

As a Postdoc in Dr. Barrett's lab, working independently but in close cooperation and consultation with the Principal Investigator (PI) and other Research Scientists, you will perform routine and complex laboratory procedures throughout training period and may develop, adapt, and implement new research techniques and protocols. This position will design and perform experiments on human intestinal organoids derived from iPSC, including the generation and maintenance of iPSC and intestinal organoids. Functional analysis of these intestinal organoids by ICC, qPCR, flow cytometry and western blot will also be required.

Job Duties and Responsibilities:

  • May assist in preparation of grant proposals, but is not responsible for generating grant funds.

  • May participate in publications and presentations as author or co-author.

  • Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the PI.

  • Analyzes, interprets, summarizes and compiles data.

  • Operates and maintains equipment and instruments.

  • Participate in laboratory meetings, keeping a lab notebook, performing calculations, tabulating data, summarizing methods and results of related experiments and general lab maintenance.

  • Collaborate efficiently and cooperatively with a team of faculty, research associates, technicians and students.

Educational Requirements:

  • Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization.

Experience and Skillset:

  • Works independently on research projects designed by a mentor (typically the PI) within area of specialization. Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.

  • Previous experience in micro-array and RNA-seq analysis, preferred

  • Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, operation and maintenance of specialized equipment.

  • Knowledge of safety standards.

  • Excellent written and oral communication skills.

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law.

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